We are a multi-disciplinary team working on drug-resistant infections

ADILA: Antibiotic Data to Inform Local Action

The project aimed to develop open-access analyses and tools to guide national and local antibiotic prescribing policies. Key objectives included developing a methodology for deriving AWaRe-based national antibiotic targets, AWaRe quality indicators, methodology for collecting antibiotic prescribing data in primary healthcare, and for estimating expected antibiotic use in hospital and primary care based on clinical burden.

Partners: University of Antwerp, University of Oxford, Liverpool School of Tropical Medicine, Mahidol Oxford Tropical Research Unit,
Cambodia Oxford Medical Research Unit, National University of Singapore, Kenya Medical Research Institute

Researchers: Profs Michael Sharland and Catrin Moore at City St George’s, University of London, Dr Koen Pouwels at Nuffield Department of Primary Care Health Science and Dr Ben Cooper at Centre for Tropical Medicine and Global Health at the University of Oxford

Funders: The Wellcome Trust

Website: Antibiotic Policy Group – ADILA

CAST-UTI: Comparison of community and hospital Antibiotic use practices, Susceptibility and resisTance and determinants of care seeking among patients with Urinary Tract Infections.

This pilot study examines antibiotic resistance in acute urinary tract infections across two socioeconomically diverse Kampala neighbourhoods. The research investigates patients who visit community pharmacies and outpatient clinics, comparing local resistance patterns with WHO Uganda data whilst examining prescribing practices, patient demographics and multi-drug resistance prevalence.

Using phenotypic and genomic techniques, together with social science to understand the patient pathways for treatment. The study aims to establish a framework applicable to other low- and middle-income countries, facilitating intervention strategies to promote appropriate antibiotic use and reduce antimicrobial resistance-related mortality.

Partners: Makerere University, Infectious Disease Research Centre, BioAmp, UTI-lizer
Researchers: To be added
Funder: The Wellcome Trust

Outputs

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CURE: The Comprehensive Understanding of Disease and AI Research project

The CURE project addresses antimicrobial resistance by creating a comprehensive global data landscape mapping clinical, microbiological and antimicrobial use information. Using novel artificial intelligence tools, the project will describe the data landscape and begin to harmonise disparate datasets by outlining a common data platform that could be used. With SmartBiotic the team are harmonising data, using AI algorithms to enhance and fill gaps in currently existing clinical microbiology data which is informing evidence-based treatment guidelines. Through systematic reviews and collaboration with international experts, CURE will develop freely available tools that establish a scalable platform for AMR data, with future expansion planned across the One Health framework to support global efforts in reducing inappropriate antibiotic prescribing.

Partners: SmartBiotic, University of Leeds

Researchers: Dr Anne-Sophie Jung, Prof Ed Alonso, Dr Fredrick Mutisya, Louis Vezard, Taïoh Yokoyama, Dr Sana Boujaafar, Dr Mathieu Raad, Prof Catrin Moore

Funder: iiCON & UKRI

Knocking out AMR:

Prof Moore co-leads the Microbiology Society’s Knocking Out AMR project, a four-year initiative addressing the global antimicrobial resistance crisis. The project has convened 135 experts across One Health sectors to develop solutions in surveillance, diagnostics, vaccines and policy. Prof Moore led workshops in 2025 using an innovative complex systems approach. The initiative identified barriers and interventions, with findings published online. Prof Moore leads engagement activities including the AMR in Focus series, educational resources and collaboration with UK health agencies, representing the Society at high-level policy meetings including the 2024 UN General Assembly on AMR.

Website: Knocking Out Antimicrobial Resistance | Microbiology Society

The Fleming Fund Fellowship in Eswatini:

This Fellowship Scheme strengthens antimicrobial resistance workforce capacity by supporting professional development of practitioners within government institutions across Fleming Fund countries. Our team of mentors in CSG and RVS mentor fellows in specialised disciplines, they are in turn training their colleagues using their newly acquired skills. The programme focuses on advanced scientific and leadership development, bringing together human, animal health and environment professionals through a One Health approach. The team are currently supporting nine fellows in Eswatini, the scheme enhances capabilities in AMR diagnostic data collection, surveillance, data management and practical application to improve national AMR response. Two of the current Fellows recently ran a workshop on microbiology quality improvement in Piggs Peak, Eswatini which was supported by this work and the British High Commission in Eswatini.

Partners: Royal Veterinary College, University of London

Beneficiary Institutions: Eswatini Ministry of Health, Department of Veterinary Services – Central Veterinary Laboratory, Hlathikhulu Government Hospital, Good Shepherd Mission Hospital, Department of Water Affairs, Ministry of Agriculture Veterinary Public Health Division Food Hygiene Laboratory, Mbabane Government Hospital Laboratory

Mentors: Prof Catrin Moore, Prof Jodi Lindsay, Dr Yingfen Hsia, Dr Kurt Arden, Dr Sian Frosini, Dr Steven van Winden, Prof Anette Loeffler, Prof Tariq Sadiq, Dr Peter Crook, Dr Lauren Hookham, Dr Richard Booth, Dr Sally Baker

Mentees:
Andiswa Tenkhosi Dlamini – AMR Laboratory – Human Health
Bongiwe Elizabeth Ngozo – AMU-C Surveillance – Animal Health
Makhosazana Shongwe (Khosi) – AMR Laboratory – Environment
Precious Mumbi Chishimba – AMU-C Surveillance – Human Health
Nelisiwe Euphene Khumalo – AMU-C Surveillance – Animal Health
Melusi Welcome Mthembu – Antimicrobial Stewardship – Human Health
Nomcebo Fortunate Zondo – Antimicrobial Stewardship – Human Health
Bavukile Siphosethu Kunene – Antimicrobial Stewardship – Animal Health
Sifundo Patience Zwane – AMR Policy – Human Health

Alumni:
Mcolisi Buyisizwe Fakudze – AMR Laboratory – Animal Health
Zizwe M. Cindzi – AMU/C – Animal Health
Ronnie Mkoko – AMR Surveillance – Human Health
Sihle Gamma – AMU/C – Human Health

Funder: Department of Health & Social Care

Website: Fleming Fund Fellowships

The Fleming Fund Technical Assistance for Clinical Engagement Africa & Asia:

Building on the ADILA initiative, the teams role in TACE is to enhance antimicrobial use data and quality across low- and middle-income countries in Africa and Asia. In partnership with IVI (Asia lead) and Fondation Mérieux (African lead), the project strengthens local surveillance and stewardship through training, technical support and through the use of data analysis tools. The TACE project promotes appropriate antibiotic prescribing using AWaRe Quality Indicators and a visualisation dashboard, enabling healthcare teams to integrate data into clinical care. The project empowers countries to address antimicrobial resistance through targeted, context-specific strategies based on local evidence.

Partners: University of Oxford, Global Point Prevalence Survey, International Vaccine Institute, Fondation Mérieux

Funder: Department of Health & Social Care

Websites: TACE AFRICA | TACE ASIA